产品货号：
Z24921
中文名称：
RAG2抗体
英文名称：
Anti-RAG2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RAG2 Antibody |
| 指标别名 | RAG 2;RAG2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | RAG2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human RAG2 (498-527aa KKPPMKSLRKKGSGKILTPAKKSFLRRLFD),different from the related mouse sequence by three amino acids. |
| 实际分子量 | 59KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Recombination activating gene 2,also known as RAG-2,is a protein that in humans is encoded by the RAG2 gene.This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development.This protein forms a complex with the product of the adjacent recombination activating gene 1,and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences.The recombination activating gene 1 component is thought to contain most of the catalytic activity,while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA.A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components,specifically with histone H3 that is trimethylated at lysine 4.Mutations in this gene cause Omenn syndrome,a form of severe combined immunodeficiency associated with autoimmune-like symptoms. |
| Uniprot ID | P55895 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | recombination activating gene 2 |
| 蛋白名全称 | V(D)J recombination-activating protein 2 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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